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Symbol Name ID |
Socs1
suppressor of cytokine signaling 1 MGI:1354910 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Acute myeloid leukemia |
| Disease(s) Associated with SOCS1 | |
| acute myeloid leukemia |
| Mouse Phenotypes | hematopoietic system phenotype |
thymus cortex atrophy |
absent thymus corticomedullary boundary |
enlarged thymus medulla |
thymus hyperplasia |
small thymus |
thymus atrophy |
decreased thymocyte number |
abnormal T cell differentiation |
abnormal CD4-positive T cell differentiation |
extramedullary hematopoiesis |
decreased bone marrow cell number |
decreased eosinophil cell number |
decreased hematocrit |
thrombocytopenia |
decreased B cell number |
decreased pre-B cell number |
abnormal T cell subpopulation ratio |
decreased CD4-positive, alpha-beta T cell number |
increased CD4-positive, alpha-beta T cell number |
increased CD8-positive, alpha-beta T cell number |
increased NK T cell number |
decreased effector memory T-helper cell number |
increased regulatory T cell number |
increased activated T cell number |
decreased lymphocyte cell number |
decreased leukocyte cell number |
abnormal mature B cell morphology |
abnormal follicular B cell morphology |
abnormal CD4-positive, alpha beta T cell morphology |
abnormal CD8-positive, alpha beta T cell morphology |
abnormal spleen morphology |
increased spleen red pulp amount |
abnormal spleen white pulp morphology |
absent spleen germinal center |
abnormal lymphocyte physiology |
abnormal T cell physiology |
abnormal CD4-positive, alpha-beta T cell physiology |
abnormal T cell activation |
abnormal macrophage physiology |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||
| Socs1tm1.1Ayr/Socs1tm1.1Ayr | |||||||||||||||||||||||||||||||||||||||||
| Socs1tm1Jni/Socs1tm1Jni | |||||||||||||||||||||||||||||||||||||||||
| Socs1tm1Kish/Socs1tm1Kish | |||||||||||||||||||||||||||||||||||||||||
| Socs1tm1Wehi/Socs1tm1Wehi | * | ||||||||||||||||||||||||||||||||||||||||
| Socs1tm2Wehi/Socs1tm2Wehi | |||||||||||||||||||||||||||||||||||||||||
| Socs1tm1Ayos/Socs1tm1Ayos Tg(Tek-cre)1Ywa/0 (conditional) |
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| Socs1tm1Ayos/Socs1tm1Ayos Tg(Lck-cre)1Jtak/0 (conditional) |
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| Socs1tm1Ayos/Socs1tm1Ayos Foxp3tm4(YFP/icre)Ayr/Foxp3+ (conditional) |
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| Socs1tm1Wehi/Socs1tm3Wehi Tg(Lck-cre)I57Jxm/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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